Hi everyone,
I meant to set up the postherpetic neuralgia model.
I can`t find any evidence regarding the Vzv viremia in rats.
Is the virus still functional?
I am writing a biosafety application, basically the committee is asking me could the rats infect the Bioresource staff?
Since infected rats show seroconversion, it is expected that they present viremia. Please see Pathogens 2013, 2, 364-382; doi:10.3390/pathogens2020364, ISSN 2076-0817, www.mdpi.com/journal/pathogens
Thanks very much for the review. There isn`t any report on functional viruses in Vzv infected rats. One group checked with PCR two weeks after infection and could not detect anything. The review you have attached mentioned the lack of viral replication in this model.
VZV can travel to ganglia in rats. It is unclear how or when VZV travels to the ganglia following primary infection, but two hypotheses exist. The first proposes that the sensory nerves of the dorsal root terminating within the dermis become infected either by the release of cell-free virus following epidermal infection or due to the cell-to-cell fusion of infected cells with neuronal axons [21,22]. The second hypothesis postulates that VZV accesses distal neurons via a hematogenous route, specifically by infected T cells during the viremic stage [21]. Thus, I assume there is a viremic stage; it could be short, but still can present.
Thank you Enas,
I have received great advices from Prof. Catherine Sadzot-Delvaux.
All the best
Welcome. It would be great if you can share the advice from Prof. Catherine Sadzot-Delvaux. Wish you all the best.
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