Rejection is a natural part of the publication process. Most authors face rejection several times before their work ultimately gets accepted.

Better to focus on following points to enhance the acceptance of your manuscript;

Emphasize the “why” factor in your article

Present well-structured content (cut down superfluous content and focus on quality content)

Accurate citations: Make sure to add relevant references to prove the work

Enrich your paper with research metrics (figures, tables, graphs, etc.).

During subsequent submission no one tells that the manuscript was earlier rejected. We should try to understand why the manuscript was earlier rejected, then improve it before resubmission elsewhere. If it is repeatedly rejected then it has to be accepted that the manuscript was not up to the mark.

Dear Subir Bandyopadhyay thanks for your reply sir. Is there anyway that the journals can know that a paper has repeatedly been submitted to other journals and without evaluating it properly they desk reject it?

Dear Ajit Singh thank you so much sir for your reply. However, frequent rejection is heartbreaking and a time consuming process.

@Subir Bandyopadhyay sometimes a rejected manuscript form a journal is submitted to some other journal with slight changes and if it goes again to the same reviewer, it gets rejected again. However, usually it does not happen and the same rejected paper gets published in some other jurnal with many mistakes.

Dear Tapas Chakrabarty Thanks very much for your reply sir. I completely agree with you.

@Mohammad Razib Hossain

As mentioned by Tapas Chakrabarty the journal comes to know about the earlier rejections if the manuscript is by chance sent to the same reviewer

There are many reasons why manuscripts get rejected. Whatever the reason is, it is always better to receive comments on your manuscript so you can address them and it certainly leads to submission with more improvement until it is reshaped to an acceptable version.

Hello Mohammad Razib Hossain

I think the answer to your question is yes and I take the point of Sayed Afzal Shah and say that I strive to improve my manuscript then send it again. I think the chance that my manuscript would be reviewed by the same reviewer as suggested by Subir Bandyopadhyay is low for most fields but if it is relatively a close community like in some areas/topics then that might be more likely a problem. I have never experienced that before myself (either as an author or reviewer).

Never multiple rejection reduce accptance of manuscript but give more chance of acceptance by take inconsedration all corrections and objective points by reviewer.

Dear Subir Bandyopadhyay thank you again sir for your reply.

Dear Sayed Afzal Shah thank you sir for your reply. I agree with you; however, if the paper is desk rejected by the editors then it is not possible to receive any suggestions but a sad note stating that "Sorry your paper is not suitable for this journal".

Dear Joseph C Lee thank you so much sir for your insightful reply. However, most of the papers do not make it to the initial screening and get desk rejected. What would be the future for those papers?

Dear Salameh Barhoom thank you sir for your reply. What if the paper does not receive any suggestions and gets desk rejected?

Dear Dr Mohammad Razib Hossain

Absolutely no because from

each rejection you take the reason of the rejection and according to this reason you modify your paper to be stronger than before . Finally, your paper will be stronger and has more chance to be accepted.

Dear Aref Wazwaz thank you so much sir for your reply. I do agree with your thoughts. However, if a paper is desk rejected by an editor what would be the suggestion for that paper?

I do not think so because after the rejection you can change your work to solve the possible problems alleged by the newspaper, improving it significantly and being accepted in another periodical.

In today’s world it is true that an excellent paper can be rejected because standards are being set making the rejection persentage in journals a measure of  " quality » if this is applied blindly. However a good original paper will finaly be published despite the growing obstacles.

Dear Mohammad Razib Hossain,

Some top ranked journals have a high desk rejection tendency. I agree with you - a desk rejection does not add any value to a manuscript. However, you can find out a new ranked journal for a new submission. Hope the new submission would not be received by the same reviewer/s. As a strategy, you can collaborate with a recognized scholar in the field to avoid desk rejection. Moreover, you can use a recognized data set or ensure the validity and reliability of the study with sufficient support. Hope it would help you to avoid desk rejection.

Dear Mohammad, multiple rejection gives one an opportunity to improve the manuscript based on comment received from the journal.

Dear Jose Roberto Rasi thank you sir for your reply. I do agree with you; however, for papers that get desk rejected have to accept a different fate.

Hello, again, Mohammad Razib Hossain

My personal experience is that I obviously have had manuscripts rejected before. On all occasions, I realised that I just have to send it again (to another journal, of course). The senior researchers (very experienced) said "don't worry, it will go somewhere". So I agree with Najib Abou Karaki although do not have a nice picture to say that! What I mean is if it is a good study/paper, it will be accepted but it will require patience - which is something that is not easy for me!

Dear Najib Abou Karaki thanks for your comment. Nice pictorial presentation by the way. I do completely agree with you that papers with highest quality ultimately makes to publication.

Dear Imranul Hoque Thank you sir for your reply. Sir, I fully agree with your thoughts too. I also believe that collaboration with other scholars will certainly help in reshaping the manuscript.

Dear Ali A. Al-Homaidan thank you sir for your reply. Sir don't you think that after each rejection the authors suffer from psychological issues, depression and anxiety? There are times when multiple rejections discourage to resubmit the paper to a new peer-reviewed journals.

Dear Osaretin Christabel Okonji

Thank you so much mam for your reply. I do agree with you; however, what can be done if the paper gets desk rejected multiple times?

Dear Joseph C Lee

Thank you again sir for your reply. I do agree with your views. Patience is the most important factor here that actually motivates you to move further. After each rejection the authors go through depression and anxiety which is difficult to recover.

Hello, again, Mohammad Razib Hossain

This sounds stupid but for my depression and anxiety after (another) rejection, I do more physical and repetitive things - usually long runs. I find that helps me in those times...! It is a good time for me to also think what I can or should do to change or improve the manuscript (or not at all).

Dear Joseph C Lee

Hello sir. I think you should do anything that will help to boost your enthusiasm and energy to go for a new research.

Dr. Mohammad Razib Hossain,

You're welcome.

Agree with some of the other replies above... multiple rejections only offer an author more chances to improve their work.... Please keep trying!

Dear Patricia Ann Herlihy thank you so much for your comment.

Dear Muhammad Aledeh

I also suffer with same rejections. But I never lose hope until now. I am still reworking and submitting for next journals my those rejected papers.

Dear Shuraik Kader thanks for your reply and the inspiration.

I totally agree with other renown researchers on here that multiple rejection of manuscript does not diminish the chance of acceptance of such paper by another suitable journal. As a young and budding researcher, rejection of submitted manuscript by a target journal could be depressing and highly discouraging to say the least. Some editor-in-chiefs are blunt and intimidating in communicating their rejection correspondences to the author(s). Bottom line is that a budding researcher should develop mental "shock absorber" to handle any paper rejection (or perceived paper discrimination) and see such rejection as an opportunity to improve the quality of the paper for re-submission to another high-impact, suitable (if not better) journal. Thanks!!!

Dear Seyi Festus Olatoyinbo thank you so much for your comment. Also that you for the inspiration and good luck to your new empirical endeavors.

@ Dr. Mohammad Razib Hossain Thanks for your kind & uplifting comment. You are highly appreciated. Cheers!!!

If the suggested modifications are not met, a peer-reviwer would continue disapproving the publication of the manuscript. This is, at least, what I do as a peer-reviewer. Moreover, if the submitted paper doesn't match the journal's scope as you state in the question, it is most unlikely the paper would be approved!

Dear Ahmed T. Hussein thank you sir for your reply.

NO.