Do increasing humidity, saline nasal sprays, nasal xylitol have role in reducing such problems?

21 January 2016 1 4K Report

If the one airway hypothesis is correct and upper airway irritants effect the lower airway, then cleaning the upper airway should reduce lower airway problems. Do increasing humidity, saline nasal sprays, nasal xylitol have role in reducing such problems?

Alonzo H Jones

So are there any studies showing a benefit in a specific problem–like asthma–from efforts to clean the upper airway?

More Alonzo H Jones's questions See All

How do you convert Erlang B into hospital bed occupancy?

Some years ago I adapted the Erlang B equation into the equivalent to Hospital bed occupancy and admissions turned-away. I have forgotten how I did this. How do I turn the offered load in Erlangs...

02 April 2024 313 0 View

How do you compare age standardized mortality rates (ASMRs) calculated using different standard populations?

I am looking to compare the slope of the relationship between hospital bed demand and age standardized mortality rates (ASMRs) between countries using different standard populations. Is it...

18 March 2024 328 1 View

What sequencing depth should I use for a Metagenomic AMR study of river water?

I am planning my PhD project and would like advise on the appropriate sequencing depth for understanding AMR genes and taxonomy from river water that is not considered to be heavily polluted, So...

21 February 2024 5,000 0 View

Why does the beam move when switching between focus and record in low dose mode using serial EM?

Refer to uploaded video. When using serial EM in low dose mode the beam is moving when switching between focus and record. This results in bad images that are blurry. Anybody encounter this...

24 January 2024 736 2 View

How many serial bone marrow aspirations from femur on live mice is humane?

What are people doing to repeated bone marrow aspirations in mice from femur? 1 or 2 weeks in between draws? Alternating legs? How many max per mouse? Thanks in advance !

29 November 2023 597 1 View

Has anyone tried oral administration of drug by mixing with rodent chow and using a sweetener to ensure palatability of chow?

I wish to mix CBD into rodent chow as well as WIN 55, 212-2. Because WIN is a schedule 1 drug, I'm not able to have this premixed by a reputable vendor. I was thinking of using either glycerol or...

19 October 2023 7,902 0 View

Does the electron beam need to be in the center of the screen when aligning the objective aperture?

When aligning the objective aperture on a F30 in diffraction mode, does the electron beam need to be in the center of the screen? For example look at the picture I have shared. The beam is off...

15 October 2023 2,051 2 View

Why does my DAPI appear streaky on mouse brain tissue?

Hello, I am working on optimizing some antibodies for immunofluorescence IHC in my lab and I am having issues with getting my DAPI to stain properly. I'm also trying to optimize my IHC protocol...

10 October 2023 7,647 4 View

Are there any good guidelines on the practical application of Critical Realism to mixed methods ( quals and quants), especially quants ?

I am looking for some guidance which indicates clearly how CR is applied to the methods/ methodology of mixed methods( especially the quantitative elements) research. I am finding it very...

02 October 2023 3,149 4 View

Why is my clarified lysed insect cells clogging IMAC column?

Hello. I am working on heterologoulsy expressing and purifying a protein using the Bac-to-Bac method. The protein expresses as verified by western blotting. I typically do a 4.2 L expression...

13 August 2023 7,778 9 View

Are there researchers with prior experience in conducting nasal washes on mice for immune cell characterization via flow cytometry?

Particularly interested in gathering tips and strategies to optimize cell yield during collection. Any insights on maximizing the number of collected cells would be invaluable

15 August 2023 5,809 0 View

Has anyone used a lower volume of Qiagen's RNAprotect Saliva Reagent than the 1 ml noted in the manufacturer's protocol?

We are isolating cells from nasal lavage fluid and saving them for RNA extraction. We recover between 20,000 and 1 million cells and would like to use a lower volume if it will not affect our RNA...

19 July 2023 7,393 0 View

What are the latest recommendations regarding the use of stents after repairing choanal atresia ?

Choanal atresia is a congenital blockage of the posterior end of the nasal cavity.

18 June 2023 2,692 2 View

What is the minimum FOV size required to develop a deep learning model for automatic diagnosis of sleep apnea using CBCT images?

What is the minimum FOV size required to develop a deep learning model for automatic diagnosis of sleep apnea using CBCT images? Also, does it need to include the entire structure from both nasal...

22 March 2023 992 1 View

Calculation of PDE for nasal drug?

Is it worth changing the approach to calculating PDE for nasal medications? Nasal drug/spray is characterized by systemic and local action. Is it necessary to enter an additional SF into the...

28 November 2022 7,052 3 View

I am looking for protocol to expand Nasal T regulatory cells for restimulation, anyone with an Idea?

I aim to look for pneumococcal specific T regulatory cells in nasal mucosa, however, we seem to have very few of these cells. I was wondering if I can expand these cells for re-stimulation.

09 October 2022 6,619 0 View

Can we get the sugar content of different sweetener using HPLC DAD?

I want to see if I can see the sugar content, for example sugar alcohol(xylitol), using DAD HPLC

22 June 2022 697 1 View

Why FDA approved nasal spray of (S)-ketamine for treatment-resistant depression instead of (R)-ketamine in 2019?

I have read some articles mostly in which (R)-ketamine was revealed as a safer antidepressant with more efficacy than (R, S)-ketamine and (S)-ketamine. Hence, my question is why FDA approved nasal...

12 June 2021 8,941 6 View

Is there a way to calculate the concentration of mucus in a nasal wash sample?

I need to calculate the concentration of viral antigens or viral load in a given amount of mucus in an adult experimentally infected with RSV. The only comparable test I have come across in the...

01 October 2020 9,428 1 View

Where can i find a Mini-ussing chamber in México? or How may i import it online?

I'm currently working in a project in which it would be useful to measure: transmural flux, resistence and potencial difference in mucosa biopsies. I've been reading about this method and as far...

23 September 2020 7,203 1 View