I am interested in the relationship between diet and FTO gene expression. Most studies have been performed on FTO expression changes in hypothalamus. But as we know, FTO is expressed ubiquitous. We are going to do a research on this subject in adolescents in Iran and I look forward to hearing from everybody that can help us.
Thank you
i can give you genral idea ,
diet is sourse of micronutrient and marconutrient . indivual nutrient such as mineral , phytochemical a peak level is nesseary for any gene expresson require , phytochemical may increase or decrease maybe involve repair system . you shoud be first reconize nutrient need in FTO exoression then their source food with proper bioavilbilty. i think its effect lipid metabolism, so if you give high lipotropic factar rich diet like Zn,Mn,Se, mufa, vitamin E , B12, etc
then see effect.
Thank you for you response
Studies in recent years has been shown the FTO role in cell metabolism through mTOR pathway. so we expect the FTO gene expression can influenced by many dietary factors such as calorie intake, dietary protein, dietary fat and so on.
But about The gene expression changes in blood cell, we don't know anything...
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