From these studies, it can be summarized that the use of corticosteroids in third molar surgery appears promising in reducing post-operative discomforts or sequelae. Fourteen studies reported the benefit of corticosteroids on all 3 sequelae, with 71.4% resulting from methylprednisolone use. It is almost certain that swelling and to some extent trismus will be significantly reduced with the use of corticosteroids. It appears that the potential analgesic effect of corticosteroids holds promise to enhance their further acceptance into routine dental practice, although their role in pain control remains debatable. More studies should therefore be carried out to confirm if the analgesic effect results from the synergistic effects with NSAIDs and/or local anesthetic agents. Assessment of the sequelae should be done with more accurate and precise assessment tools so that the results of these future studies will have an impact on the best route and corticosteroids to be used, taking into consideration its efficacy and side effects as well as cost and whether its usage is economically feasible to be adopted in routine practice.