Dear all,

In my project I am using CAR NK cells for the lysis of target (in this case tumor) cells. Since our NK cells are injected into the brain, I looked into NK cell mediated cytotoxicity towards brain resident cell types like astrocytes or microglia. In various assays those cells appeared to be more resistant to NK cell mediated lysis, although they express the target antigen, so I did some literature research and apparently there is some evidence that astrocytes as well as microglia seem to have higher tolerance towards e.g. perforin.

Since those cell types contribute to the function of the immune system, I figured they would benefit from being less suspectible to cytolytic processes around them during an immune response. However, I hardly found any data/publications on this, so I thought maybe you could help me out.

Do any of you have some more thoughts or ideas or maybe even some evidence regarding this matter? That would be great!

Really looking forward to your input! Thank you very much in advance :-)

Maja