We have just completed a shotgun metabolomic analysis of maternal urine from women carrying a Downs fetus - we have some interesting metabolites and wish to link to fetal and perhaps post partum Downs Individal liver enzyme deregulation. I don't want to name the metabolite positively identified as I don't want to bias any responses. We really want to know what is known rather than tunnel vision to create support to match what we found.
We'vent found any usual liver enzymes increase in "healthy" people with trisomy 21. Only whwn they have some comorbidities, sich as antiepileptic treatment, or steatosis we've found liver enzymes changes. Please. look to my profile about our expertise in the field. I'll be glad to collaborate for anything in the field.
Best wishes
Corrado Romano
Dear Corrado
Many thanks I was just downloading some of your papers - and I will email you details of uracil metabolism alterations detected. We would very much welcome joint collaboration
Yours truly
Ray Iles
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