Has anyone encountered changes in the chemical shift peaks while employing different deuterated solvents (CDCl3, DMSOd6, CD3OD, etc.) for the same organic sample. Especially in compounds containing OH, NH, etc.
Yes, this is a common phenomenon. It can for example be observed in the tables of these publications: Article NMR Chemical Shifts of Trace Impurities: Industrially Prefer...
Article NMR Chemical Shifts of Trace Impurities: Common Laboratory S...
This why it is important to report the solvent (and if applicable pH) of the NMR samples when publishing NMR data.
Yes . This is known as solvent shift. I did for the identification of methoxy groups in Biflavonoids.
Short answer is sure, chemical shifts vary in different solvents, usually to the minor extent. Specifically, both OH and NH groups may form hydrogen bonds including such bonds with groups present in deuterated solvents. Such solvents as D2O, CD3OD, CD3CN, and DMSO-d6 possess the groups that are H-bond donors, acceptors, or both. In these cases, the difference between chemical shifts in CDCl3 and in these solvents may be significant.