Geetmani Singh Nongthombam

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Questions related from Geetmani Singh Nongthombam

Do 1H-NMR peaks shift appreciably while employing different deuterated solvents?

Has anyone encountered changes in the chemical shift peaks while employing different deuterated solvents (CDCl3, DMSOd6, CD3OD, etc.) for the same organic sample. Especially in compounds...

29 December 2023 5,403 5 View

Is it possible to carry out molecular dynamic simulation and obtain RMSD curve/plot using AutoDock Vina (AutoDockTools)?

Binding sites along with binding energy can be easily determined using ADT. However, MD simulations have been reported by researchers using Schrodinger Desmond. So I was wondering if there is a...

29 December 2023 177 6 View

Is it accurate for a ligand to dock at a specific protein site different from the reported inhibitor?

Is it mandatory that the grid box has to be localized specifically at the same exact site where the reported inhibitor binds to the receptor? Is there any relevance for carrying out blind docking...

28 December 2023 5,273 2 View

Can we use THF as solvent for BuLi aided formylation when the reactant is insoluble in THF?

Formylation reaction of an arylbromide derivative using Butyl Lithium and 1-formylpiperidine is usually carried out in dry THF. Here if the arylbromide derivative is insoluble in THF will the...

13 September 2021 5,752 5 View

How to remove unreacted barbituric acid from a reaction mixture?

In literature, it is reported that barbituric acid is soluble in water, however, it appears to have solubility issues and as such it does not dissolve completely in water or alcohol.

26 July 2016 9,950 6 View