Dissolving 100 kDa PLGA in an organic solvent?

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Muhammad Naeem

Try to use water bath sonication. it dissolve after 10-20 minutes. Hope it will work for you.

Hasan Yildiz

Thank you, let me try that way

Raghd Muhi Al-Deen Jassim

it is soluable in water, dear

PLGA is not soluble in water, especially 100 kDa..20 min sonication solubilize the PLGA but it also alters the structure as I was getting the same size particles with 50 kDa

open this link to see SDS from Sigma http://www.sigmaaldrich.com/MSDS/MSDS/DisplayMSDSPage.do?country=IQ&language=en&productNumber=802182&brand=ALDRICH&PageToGoToURL=http%3A%2F%2Fwww.sigmaaldrich.com%2Fcatalog%2Fproduct%2Faldrich%2F802182%3Flang%3Den

Below is the answer from a Sigma scientist regarding to my question:

Thank you for contacting Sigma-Aldrich Technical Service, now MilliporeSigma - the life science business of Merck KGaA, Darmstadt, Germany.

Unfortunately, we do not test the maximum solubility of any of our products. We also do not test solubility of 802182 so this would need to be verified experimentally.

try BTX