Dissolution Medium pH:6.8 Buffer and 4.5 Buffer?

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Sachin B Morge

We can use 4.5phosphate buffer as per their requirment.

Małgorzata Jaworska

In pH 4.5 phosphates can not "produce" buffer capacity because pKa of phosphates is about 7,2. Actetates of pKa about 4.8 are able to form good buffer in pH range 3.8-5.8 (pKa ± 1).

Pankaj Joshi

Agreed with Malgorzata Jaworska.