Please suggest...How to solubilize the Disodium EDTA in Ethanol(99%) ?
As My product composition contains 52% ethanol(99%) and EDTA 0.1%.
Product is Non-aqueous.
thanks...
Dear Sagar,
Use Cosolvent(like propylene glycol) in which Disodium EDTA is dissolved and also cosolvent is miscible with ethanol.
Disodium EDTA once solubilization in water and then addition in ethanol. It will re-precipitation.
Water i can use maximum 5%w/w
Ethanol 52%w/w
Disodium EDTA 0.1%w/w
Some things I would do:
Make sure you are using the disodium EDTA salt and not the acid (or neutralize it).
Check the pH of the solution (should be around 8.5), you can add NaOH or KOH (which are fairly, around 1g/ml, soluble in ethanol) progressively and shake after each addition until completely solubilized.
Heat the solution while stirring with a magnetic pellet (EDTA is stable to temperatures far beyond boiling point of ethanol), but watch for vapors, and keep off ignitions sources.
Check the order of adding things to your final product to look for other steps it may be added in, in which more water is available. Hope this was helpful.
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