I wanted to see if plant extract could up-regulate the expression of BDNF promoters better than the commonly prescribed drug being fluoxetine,after depression was induced by force swim model (FSM).However in 3 promoters of BDNF,it was seen that there was more expression of BDNF by fluoxetine treatment on depressed subjects than in the normal healthy subjects. More expression BDNF was seen in depressed animals treated with fluoxetine than in healthy subjects,what could be the reason for such observation?
It can have to do with forced swim model. Our PD models were subject to wheel running with the same result. Running wheel activity restores MPTP-induced deficits is our paper that you can download from RG.
There was no administration of MPTP. Animals were subjected to FSM followed by treatment (fluoxetine and B.disticha extract), then animals were sacrificed. Then the BDNF expression levels were evaluated.
More expression of BDNF in depressed subjects compared with healthy ones might have to do with some compensation mechanism. BDNF levels are generally lower in patients who suffer from a psychiatric illness, including depression than in healthy individuals. The kicking effect of antidepressants might turn it upside down in the context of compensation.
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