Solubilization seems a plausible procedure, applicable at least in case of membrane proteins.

You can check my PhD thesis for details. Good luck!

You can try TX-114 phase separation.

Methods:

- Polson et al. and Jensenius and Koch , using dilution buffer and

precipitation with PEG 8000 to 3.5% or 4.4%

-Jensenius et al., precipitated with dextran sulfate and CaCl2

-Akita and Nakai, diluted with acidify and two water without precipitation at 19% and

14% Na2SO4

-Akita y Nakai, diluted with water and acidified to pH 5.0 precipitation with (NH4) 2SO4 to 60% s