Dear researchers, Can anyone please suggest upon the solubility of Imiquimod ?

11 October 2023 1 2K Report

I have tried dissolving the same at 1mg/ml in both water and DMSO but there was precipitate formation. I even tried heating and sonication but there was no effect as there were precipitates.

Pavel Yudaev

IMQ is a molecule highly insoluble in aqueous media; its solubility increases slightly at acidic pH because it is a weak base (pKa = 7.3). Solubility of IMQ in DMSO is 1.29 ± 0.13 mg/ml (at room temperature, under magnetic stirring).

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