Specifically, treatment-emergent affective switch "TEAS" should be discriminated against the much controversial "tolerance" upon discontinuation (then vs. continuation treatment followed by apparent loss of response). The criteria for the discontinuation syndrome should then take into account the follow-up too I think: there are some anecdotal reports by Andrade (and then myself with Dr. De Berardis as leading author) documenting recovered response (including reverted TEAS) upon sudden reintroduction. Lastly, I would recommend to stress-out the notion that discontinuation differs from jittering and from withdrawal. I would be happy to discuss this further in detail with you. Bests, Michele.

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