in the early onset of AID are you expected to be the anti-inflammatory cytokine to be increased or decreased?

if we find increased ( its correct to us to explain that as last resort of immune system to finish the fault immune response against self) but after the failure of this weapon, they start to decrease along with disease progression.

or can explain from another site of view ( high concentration of anti-inflammatory cytokines in the early onset of AID come from proteolytic cleavage to in situ high cytokine expression at the site of organ-specific AID and because of self cell destruction, then the cytokine leakage to peripheral blood and appear high in concentrations).

because as I read mostly AID researchers do not take into account the Chronology of autoimmune disease profile.

just take a snap for AID that anti-inflammatory cytokines decreased and proinflammatory increased...... that's logical but when that happens..?????

in my opinion, this picture reflects the last event when no more challenge from the immune system to correct the events.