my deceased friend Dr. J.-U. Wieding discussed von Willebrand's disease as a protection against Factor V Leiden and associated thrombosis.
My idea was 2000, that Factor V Leiden and Cystic Fibrosis (coagulation and fibrosis) are the main innate immunity against respiratory infections, especially streptokinase-producing group a streptococci. (Coming down to us from the neanderthal, those cold-proven humans.)
Hi , you might want to look at the role of ADAMTS13 in covid as an explanation for this. Lots of coagulation -inflammatory links are happening in Covid . Cheers Robyn