hello dear colleagues,
this question I would like to ask about apoptosis / necrosis phenomenon
regarding of well-known biomarkers , in case we have not checked biomarkers yet , for instance ,
could we differentiate between necrosis and apoptosis according to cells morphology ?
*example: based on this image , apoptosis or necrosis cell (blue arrow) / control normal cell (green arrow)
many thanks and most sincerely
Hello An Nguyễn Hoàng
You will observe that apoptotic cells eventually form apoptotic bodies.
Necrotic cells lose their plasma membranes and do not form such bodies, and will eventually disintegrate. So, according to me the blue arrow could be indicating an apoptotic cell.
Please refer to the link below. See Figure 15-1.
https://alg.manifoldapp.org/read/fundamentals-of-cell-biology/section/db353ee7-8050-4d91-b3e7-2ed8ce59e5e7
Best.
There are several ways to distinguish between apoptosis and necrosis, including morphological features. Briefly, apoptosis is associated with plasma membrane blabbing, cell shrinkage, and formation of apoptotic bodies, while necrosis is associated with loss of plasma membrane integrity, cell volume expansion, and leakage of cellular contents.
Regard this reference:
Article Morphological criteria to distinguish cell death induced by ...
and more recent articles
Thank you so much for your precise references and good observation. I have read in details all of your mentioned references. Now I am quite sure about the answer for this result. Again, thank you for your time and checking carefully.
Best regards,
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