Could anti-histamine drugs be administrated for newborn as hypnotic drugs?

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fatal error

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Mustafa Aydin

It is not appropriate for infants less than 2 years, especially for less than six months. Because antihistamines also are potent muscarinic receptor antagonists that can lead to serious anticholinergic side effects, such as sinus tachycardia, dry skin, hyperthermia, dry mucous membranes, dilated pupils, constipation, ileus, urinary retention, and agitation.

(Church MK, Maurer M, Simons FE, et al. Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper. Allergy. 2010;65(4):459-466.)

Nikola M Stojanovic

H1 receptors distributed through brain tissue can cause numerous sideffects that are related to CNS, to to newborns immaturity of CNS this drugs can cause sever damage. Also I agree with the mentioned other sidefects that include extra-CNS receptors and muscarinic ones...