first generation of antihistaminic drugs have sedative effect as side effect, some doctors prescribe these drugs for hyperactive newborn, what are the advantages and risks.
It is not appropriate for infants less than 2 years, especially for less than six months. Because antihistamines also are potent muscarinic receptor antagonists that can lead to serious anticholinergic side effects, such as sinus tachycardia, dry skin, hyperthermia, dry mucous membranes, dilated pupils, constipation, ileus, urinary retention, and agitation.
(Church MK, Maurer M, Simons FE, et al. Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper. Allergy. 2010;65(4):459-466.)
H1 receptors distributed through brain tissue can cause numerous sideffects that are related to CNS, to to newborns immaturity of CNS this drugs can cause sever damage. Also I agree with the mentioned other sidefects that include extra-CNS receptors and muscarinic ones...
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