Just mechanisms exerting p53 gene to link chromosome are preceded p53 gene linking chromosome via viral affected cellular DNA subjected to accelerated cellular cycle due to stimulation G1, S, and G2 phases cellular cycle which induce also by mitochondrial processes and so on. (see bellow:
1. Ponizovskiy M.R., (2019), A newer method cancer treatment which is based on Link Rearrangement Operations of T cells, International journal of Cancer and Oncology, 6(2), 42 – 51, doi:10.15436/2377-0902.19.2546 ISSN:2377-0902.
2. Ponizovskiy M.R., (2013), Biophysical and biochemical transmutation of mitochondrial function in cancer genesis, Biochemistry & Analytical Biochemistry, Volume 2, Issue 3, 1 – 9, doi:10.4172/2161-1009.1000137. ).
I think one of the things we need to keep in mind is that viruses are just one of a myriad of environmental factors that can increase risk for cancer. It has been estimated that the number of single-stranded breaks in DNA may be as high as 10x4 - 10x5 per cell per day [Iyama, 2013; Hoeijmakers, 2009], meaning that if these mutations were not repaired on a regular basis, most of us would have cancer. The question we should be asking is not why we get mutations, but what goes wrong when the body ceases to defend against them.
Dear Dr. Sarah S. Knox,
First of all, I regret that you reject viral etiology as v-oncogenes as the initial cause of Cancer. Just I would ask yours Comments on these two works:
1. Ponisovskiy M.R., (2010), “Cancer metabolism and the Warburg effect as anabolic process outcomes of oncogene operation”, Critical Reviews in Eukaryotic Gene Expression, 20 (4), 325 – 339.
2. Ponizovskiy M.R., (2018), The mechanism of cancer cellular genome disorder and comparison therapeutic effects of modern methods and new method cancer treatment, Journal of Genetic Disorders, v.2(8), 1 – 17.
Secondly, really do you consider that the disorder of repairing mechanism is the mechanism of transmutation healthy cells into cancer cells? It would be very light explanation of the compound genetic changes in cancer cellular cycle, especially in M phase (see above articles).
As concerning to my question, please explain in What phase cellular cycle it occurs production as both p53 protein and p21 protein by corresponding p53 gene and p21 gene as well as in What phase and how it occurs mechanism cancer suppression?
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