Could any one suggest me solvents for Lithiation using Butyllithium other than Ether class as my reaction is not compatible(forms more of impurities ) and preferable like Toluene(formation of product and solubility is a problem).
Rafik Karaman
Dear Sudhakar,
The reactions of n-butyllithium or t-butyllithium are generally carried out in simple hydrocarbons such as pentane and hexane, ethers such as diethyl ether or THF and tertiary amines such as tetramethylethylenediamine (TMEDA) or mixtures of two kinds of the mentioned solvents in low temperatures.
TMEDA will be a good choice to carry out your reaction in.
Köhler, F. H.; Hertkorn, N.; Blümel, J. CB 1987, 120, 2081.
http://reag.paperplane.io/00000502.htm
Hoping this will be helpful,
Rafik
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