Compare two pre-ranked gene lists in GSEA?

20 October 2020 0 463 Report

Hello!

I have a gene expression dataset that underwent several transformations, after which I ran statistical tests. Every group in the data as well as every gene underwent the same linear regression seperately - so I have an object for every group and each object has the linear regression results for each gene.

So far I ran GSEA on each **group** in the data, but as a preranked gene list, where the ranking metric is the q-value or estimate per each **gene**.

Now I would like to compare between groups - because in each group the genes are ranked differntly. Is this possible? Which metric should I use?

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