Certainly, new, safe antimicrobial components (especially from natural sources) are being investigated daily by researchers. However, such antimicrobial candidates must be selectively toxic. Also, some components are not outrightly antimicrobials but modify host cell pathways, making it less conducive for intracellular pathogens. However, since its activities would be required within the host, coupled with the idea that host metabolism could alter a presumably safe component to become toxic to such host, adequate assays and clinical tests would be required before anything translational could be thought of such agent. Basic screening procedure are freely available online I guess.

Thanks Adedire O. M.

Hi Ashutosh

I add some useful references 1

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwjIy57V4rrbAhXBDSwKHaAyBuYQFggnMAA&url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3376848%2F&usg=AOvVaw1EJ1p5hYB-8BghZB5j12ON

2

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&cad=rja&uact=8&ved=0ahUKEwjIy57V4rrbAhXBDSwKHaAyBuYQFggwMAE&url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4128363%2F&usg=AOvVaw1BHmAhP1Oy7q9fzQiPSkG9

3

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=4&ved=0ahUKEwjIy57V4rrbAhXBDSwKHaAyBuYQFghHMAM&url=https%3A%2F%2Fwww.cell.com%2Ftrends%2Fmicrobiology%2Fpdf%2FS0966-842X(00)01854-0.pdf&usg=AOvVaw0jO8vaSjFbskoZCuo2OsPl

4

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=5&cad=rja&uact=8&ved=0ahUKEwjIy57V4rrbAhXBDSwKHaAyBuYQFghMMAQ&url=https%3A%2F%2Fbpspubs.onlinelibrary.wiley.com%2Fdoi%2Ffull%2F10.1111%2Fbph.13664&usg=AOvVaw2Gpl2dFX3VQzZvcOTmg34r

5

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uact=8&ved=0ahUKEwjIy57V4rrbAhXBDSwKHaAyBuYQFghVMAU&url=https%3A%2F%2Fwww.nature.com%2Fnrd%2Fjournal%2Fv17%2Fn1%2Fabs%2Fnrd.2017.162.html&usg=AOvVaw1cvSMbl3P1FUW1pLGEIRS9

6

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=9&cad=rja&uact=8&ved=0ahUKEwjIy57V4rrbAhXBDSwKHaAyBuYQFghvMAg&url=http%3A%2F%2Fwww.mdpi.com%2F2076-2607%2F6%2F2%2F33%2Fpdf&usg=AOvVaw1MJCHLML4KjjB8-A6Q5G87

7

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=9&cad=rja&uact=8&ved=0ahUKEwjIy57V4rrbAhXBDSwKHaAyBuYQFghvMAg&url=http%3A%2F%2Fwww.mdpi.com%2F2076-2607%2F6%2F2%2F33%2Fpdf&usg=AOvVaw1MJCHLML4KjjB8-A6Q5G87

8

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=10&cad=rja&uact=8&ved=0ahUKEwjIy57V4rrbAhXBDSwKHaAyBuYQFgh1MAk&url=https%3A%2F%2Fpdfs.semanticscholar.org%2F89fc%2F44161e329318a97b0d608eeb2c7c24a334b8.pdf&usg=AOvVaw2jogR06B6g8lkhyAWLXNnv

9

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=11&cad=rja&uact=8&ved=0ahUKEwi6lp6877rbAhWQKiwKHQ8XAtI4ChAWCCYwAA&url=https%3A%2F%2Fwww.sciencedirect.com%2Ftopics%2Fimmunology-and-microbiology%2Fatypical-bacteria&usg=AOvVaw0eYTyNALAxmmDLMxdDth-X

10

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=12&cad=rja&uact=8&ved=0ahUKEwi6lp6877rbAhWQKiwKHQ8XAtI4ChAWCCgwAQ&url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS1198743X1500909X&usg=AOvVaw1rLuMIHNd17uX39_cUlPS9

11

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=13&cad=rja&uact=8&ved=0ahUKEwi6lp6877rbAhWQKiwKHQ8XAtI4ChAWCC0wAg&url=https%3A%2F%2Fpdfs.semanticscholar.org%2F89fc%2F44161e329318a97b0d608eeb2c7c24a334b8.pdf&usg=AOvVaw2jogR06B6g8lkhyAWLXNnv

12

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=14&cad=rja&uact=8&ved=0ahUKEwi6lp6877rbAhWQKiwKHQ8XAtI4ChAWCDYwAw&url=https%3A%2F%2Fwww.futuremedicine.com%2Fdoi%2F10.2217%2Fnnm.15.128&usg=AOvVaw08hJ3GcFY3V7HjazNtE-Mu

13

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=15&cad=rja&uact=8&ved=0ahUKEwi6lp6877rbAhWQKiwKHQ8XAtI4ChAWCDswBA&url=http%3A%2F%2Fpmj.bmj.com%2Fcontent%2F78%2F918%2F216&usg=AOvVaw0cBiWxO94NH-30ptfcSgl0

14

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=16&cad=rja&uact=8&ved=0ahUKEwi6lp6877rbAhWQKiwKHQ8XAtI4ChAWCEQwBQ&url=https%3A%2F%2Fwww.msdmanuals.com%2Fprofessional%2Finfectious-diseases%2Fbacteria-and-antibacterial-drugs%2Foverview-of-bacteria&usg=AOvVaw0PEIZbAU6iDdtIOtoVCd7x

15

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=17&cad=rja&uact=8&ved=0ahUKEwi6lp6877rbAhWQKiwKHQ8XAtI4ChAWCEowBg&url=http%3A%2F%2Fwww.immed.org%2Finfectious%2520disease%2520reports%2F06.16.12%2520pdf%2520updates%2FCPAM-GLNetal.-00.1.21.pdf&usg=AOvVaw32tkx7nvUf7ilf6ncREVbt

16

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=18&cad=rja&uact=8&ved=0ahUKEwi6lp6877rbAhWQKiwKHQ8XAtI4ChAWCFAwBw&url=https%3A%2F%2Freliawire.com%2Ftrogocytosis-bacterial-pathogens%2F&usg=AOvVaw0_FIZEvRYzqzHUYP47IeEr

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=19&cad=rja&uact=8&ved=0ahUKEwi6lp6877rbAhWQKiwKHQ8XAtI4ChAWCFYwCA&url=https%3A%2F%2Facademic.oup.com%2Ffemsre%2Farticle-pdf%2F36%2F3%2F513%2F18128983%2F36-3-513.pdf&usg=AOvVaw1chp2RiYshHOFnUEg-QjFF

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=20&cad=rja&uact=8&ved=0ahUKEwi6lp6877rbAhWQKiwKHQ8XAtI4ChAWCF8wCQ&url=https%3A%2F%2Fwww.molbiolcell.org%2Fdoi%2Ffull%2F10.1091%2Fmbc.e15-03-0144&usg=AOvVaw0JiXOVGIuDNh-QlDPg5GY4

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=21&cad=rja&uact=8&ved=0ahUKEwib6sHN8LrbAhWIBywKHfc0Ao84FBAWCCYwAA&url=https%3A%2F%2Fwww.frontiersin.org%2Farticles%2F204277&usg=AOvVaw3rQ0g2KxUcEhNVFYoCmorw

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=22&cad=rja&uact=8&ved=0ahUKEwib6sHN8LrbAhWIBywKHfc0Ao84FBAWCC8wAQ&url=http%3A%2F%2Fwww.discoverymedicine.com%2FRadka-Saldova%2F2016%2F09%2Fcause-of-cancer-and-chronic-inflammatory-diseases-and-the-implications-for-treatment%2F&usg=AOvVaw1aovyW316GLZI5CnmPh3gh