I am investigating the question of colonic diverticula formation. It was suggested by Mayers et al. that diverticula tend to form in the weak-spots of the muscular layer, where blood vessels passing along the taenias protrude the musculature in order to reach the submucosa. In my cryo-sections, I came across these samples (images bellow). It is 4% PFA fixed, full-thickness human sigmoid colon of a senior patient. It is not located next to a taenia as could be judged from the thickness of longitudinal muscle layer, although some vessels are clearly visible.
So is this to be considered a “weak-spot” or not? If so, should they be considered to be “normal” or pathological formation? And does circular muscle layer supposed to have these types of intrusions or should this be considered “non-normal/pathological”?
https://www.ncbi.nlm.nih.gov/pubmed/4541643
Dear Sir which is the main site of diverticula ? Ante mesenteric or mesenteric > Usually we see at ante mesenteric site .
Unfortunately, I no longer know the exact anatomical location of the given sample. A thing to note is that this is technically not a diverticulum, as the mucosa has not herniated yet. This was a reoccurring event in my microscopical examination of different patients, though it was not frequent.
Dear collegue,
I guess that the diverticula formation can have more than one mechanisme. In old patients it can be the weak muscle together with the death of the neuronal components , it leads to the hypokinetic constipation, bacterial hyper growth and toxic damage of the mucosa and sumucosal layer. In other case the main reason can be the direct hypoxy of the muscular layer after the enlargement of the colon. So it is necessary to study the case-records and the resulte of the R-study of the colon
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