Determine the volume of the core and shell of the nanocrystal using the SAXS method. Knowing the specific gravity of the core, determine the weight of one core. Centrifuge nanoparticles, rinse, dry, determine the weight of all nanoparticles. If you know the weight of the suspension and the weight of all the of the core nanoparticles, then you determine the concentration of the core of the nanoparticles in the suspension.
many thanks for your replies. They have been really helpful. One last question: i have core shell nanocrystals of the same material (lets say material X) and the core is doped with a rare earth material, will TEM or HRTEM helpful to identify the formation of the core shell structure?