Estimado Dr: muchas gracias por tener en cuenta mi opinión respecto al tema estrés oxidativo (EO). Respondiendo a sus consultas:

(i) ¿Debería redefinirse el término "estrés oxidativo" para que se relacione con condiciones más específicas que la definición original (situaciones agudas? enfermedades? ¿qué más?)

El término EO no debería redefinirse, sino especificarse, ya que en nuestro organismo se generan oxidaciones permanentemente y se inicia una situación de estrés reactiva que desafía la homeostasis celular. por lo tanto, especificar si estamos hablando de EO celular, EO tisular, EO metabólico, etc, sería la forma de contemplar en donde esta el desorden oxidativo.

(ii) ¿Qué término deberíamos usar para describir (si es que lo hay) desequilibrio entre los componentes prooxidativos y antioxidantes de un sistema?

Es muy complicado tratar de expresar un proceso complejo en un sólo término, como sucede con el término EO, pero podría decirle que tratando de simplificar los procesos biológicos el término que puede ajustar la expresión sería desequilibrio redox.

(iii) ¿Por qué deberíamos cuantificar el "estrés oxidativo" (¿Hay alguna razón para tratar de "cuantificar la SG"?).

La cuantificación del EO no se logra en un sólo valor o variable, son múltiples variables o biomarcadores que deben ser tenidos en cuenta para establecer si existe o no en ese organismo EO. La necesidad de establecer este disbalance entre prooxidantes y antioxidantes, es tratar de ayudar a prevenir lesiones irreversibles en los sistemas.

Espero mis respuestas le sean útiles Dr.

Un saludo cordial

Dra Baez María del Carmen

For a short review concerning antioxidants and their classification, please see:

VIEIRA, A.J.S.C.; SANTOS, P.M.P. “A Tentative Classification of Antioxidants: Which Role They Play when Protecting Biological Targets from Oxidative Stress Induced Damage?”, J Med Chem Drug Des (2017), 1, 1-3

DOI: 10.16966/jmcdd.101

Subject: Promotional Materials: [Antioxidants: IF 4.520] Special Issue "Oxidative Stress, Classification and Quantitation"

Dear Researcher,

I am organizing a Special Issue entitled “Oxidative stress, classification and quantitation”

in the Antioxidants (ISSN 2076-3921, http://www.mdpi.com/journal/antioxidants).

The Special Issue aims to expand our understanding and perspective on all aspects of redox status, its evaluation, homeostasis related adaptation and oxidative damage and repair processes.

https://www.mdpi.com/journal/antioxidants/special_issues/

In view of your distinguished contribution to this area, I invite you to contribute a research paper and/or a review and /or a commentary to this special issue. I am particularly interested in your view on the apparent controversy regarding the use of the term Oxidative Stress and the more recently defined terms "Distress" and "Eustress". In addition, the use of these terms relates to the possibility of quantitating OS. The problem is that the OS, as evaluated by the use of different biomarkers do not correlate with each other, namely, OS cannot be quantitated by a universal criterion and it depends on the biomarker used to evaluate it. Three complementary specific questions are:

(i) Should the term "Oxidative Stress" be re-defined to relate to more specific conditions than the original definition (Acute situations? Diseases? What else ) ?

(ii) What term should we use to describe (if at all) imbalance between pro-oxidative and antioxidative components of a system ?.

And (iii) Why should we quantitate “Oxidative Stress”

(Is there any reason to try “to quantitate OS”?).

The deadline for manuscript submission is 30 April 2020 . You may send your manuscript now or up until the deadline. Submitted papers should not be under consideration for publication elsewhere.

Please let we know if you accept my invitation and send me a tentative title and, if possible, send a short abstract to the editorial office([email protected] or [email protected])

Antioxidants is committed to rapid publication. The time from submission to first decision *is 16.1 days*; from acceptance to publication *is 4.4 days*.

Antioxidants has been accepted for coverage in the Science Citation Indexed Expanded (SCIE) in Web of Science, and received its first Impact Factor 4.520 in the June 2019 release of the Journal Citation Reports. Antioxidants continues to be covered in PubMed, Scopus, with Cite Score 4.88 and ranks 10th out of 135 (Q1) titles in 'FOOD SCIENCE & TECHNOLOGY', 63rd out of 298 (Q1) in 'BIOCHEMISTRY & MOLECULAR BIOLOGY' and 6th out of 61 (Q1) in 'CHEMISTRY, MEDICINAL'., and many other databases (Antioxidants)

Antioxidants, an international, peer-reviewed Open Access journal.

Open access is supported by the authors and their institutes.

Please note that an article processing charge (APC) of 1200 CHF (Swiss Francs) applies to papers accepted after peer review.

Thank you for your consideration.

We look forward to hearing from you.

I wish you a wonderful 2020

Kind regards

Dov

Prof. Dov Lichtenberg, Tel Aviv University, Sackler School of Medicine Tel Aviv- Yafo 69978 Guest Editor of Special Issue Oxidative stress, classification and quantitation https://www.researchgate.net/profile/Dov_Lichtenberg

Dov Lichtenberg ........................................................

Estimado Dr. Agradezco su invitación, en este periodo estaré fuera de mi oficina por vacaciones, en cuanto me reincorpore a mi trabajo analizaré su propuesta con gusto. Saludos cordiales, y buen comienzo del año 2020