What is the normal range of the partial size and the zeta potential for the chitosan nano particles ?
Dear friend Zaid Abdulhussein
The particle size and zeta potential of chitosan nanoparticles can vary depending on the method of synthesis, pH, concentration, and other factors. However, here are some general ranges for particle size and zeta potential:
- Particle size: The average particle size of chitosan nanoparticles typically ranges from 10 to 500 nm, with some studies reporting sizes up to 1000 nm. However, the ideal particle size range for various applications may differ. For example, smaller particles may be more suitable for drug delivery applications, while larger particles may be better for wound healing applications.
- Zeta potential: The zeta potential of chitosan nanoparticles is often reported as positive, due to the amine groups on the chitosan molecule. The typical range for zeta potential is between +20 and +50 mV but can vary depending on the pH and concentration of the particles.
Here are a few references for further reading:
- Qi, L., Xu, Z., & Jiang, X. (2004). Preparation and antibacterial activity of chitosan nanoparticles. Carbohydrate research, 339(16), 2693-2700.
- Thanou, M., Verhoef, J. C., & Junginger, H. E. (2001). Chitosan and its derivatives as intestinal absorption enhancers. Advanced drug delivery reviews, 50(Supplement 1), S91-S101.
- Tiyaboonchai, W., Tungpradit, W., & Plianbangchang, P. (2007). Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. International journal of pharmaceutics, 337(1-2), 299-306.
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