You might check out the work of Dr Rhett Kempe (Inorganic Chemistry II, University Bayreuth), he prepared nice Iridium catalysts for the enantioselective hydrogenation of asymmetrical ketones giving quite enantiopure alcohols (ee >99%). As far as I know these catalysts are pretty cheap compared with the common commercially available catalysts. He's got a small company which sells these Iridium catalysts if you don't want to prepare them yourself.

Use CBS catalyst for asymmetric reduction of ketones...

Check this..http://www.organic-chemistry.org/namedreactions/corey-bakshi-shibata-reduction.shtm

I am agree with Bernhard suggestion. Prof. kempe group synthesised some new amido-iridium catalyst for the hydrogenation of simple ketones in Angwante chemie 2011.

What about the asymmetric Meerwein-Ponndorf-Verley reduction ?

Your question and substrate are broad enough to require a maybe. The transformation is substrate and catalyst specific. Combi ie trial and error of a range of reagents provides a solution. It can be done but no magic bullet.

Commercially resolution chemical and enzyme work with Mutsuhito of distomer.

check this: http://www.organic-chemistry.org/Highlights/2006/05March.shtm

Please see this article Pure Appl. Chem., Vol. 71, No. 8, pp. 1493±1501, 1999 regarding your question.

RuCl2(phosphine)2(1,2-diamine) complexes act as excellent precatalysts for homogeneous

hydrogenation of simple ketones which lack any functionality capable of interacting

with the metallic center. This newly devised catalytic system allows preferential saturation of a

CˆO function over a coexisting CˆC linkage in 2-propanol containing an alkaline base.

Furthermore, the stereoselectivity of the reaction is easily controlled by the electronic and

steric properties (bulkiness and chirality) of the ligands as well as the reaction conditions.

Just look for Noyori's work on ketone hydrogenation by either transfer or true hydrogenation. Other work of intest in this context is by Walter Baratta, Rhett Kempe, or also Robert Morris of Toronto.

On of their systems should work. Companies to ask for could be Solvias or Johnson Mattay or (at least in the past) Dr. Reddy's. Good luck

Chiral ruthenium complexes are known as excellent catalysts for

asymmetric transfer hydrogenation, as Nosrat O Mahmood suggests, above. I've carried out very efficient ruthenium catalyzed hydrogenations but not specifically for chiral. products.

Take a look at: http://pubs.acs.org/doi/abs/10.1021/ja0620989

please send me the full paper if u can..

Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry

Volume 41, Issue 18, 2011

1,4-Diazabicyclo[2.2.2]octane as an Efficient Catalyst for a Clean, One-Pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives via Multicomponent Reaction in Aqueous Media

.Preview

Buy nowDOI:10.1080/00397911.2010.515345

NaBH4 reduction followed by enzymatic acylation will provide >99% ee of alcohol.

check this: http://www.organic-chemistry.org/Highlights/2006/05March.shtm

Use (R) or (S) -Me-CBS catalyst for enantioselective reduction of prochiral ketone. Best of luck.

Refer: http://dx.doi.org/10.1016/j.jorganchem.2008.08.026

I have done enzymatic reduction with bakers yeast on cyclopentanone with ester group.and yield is quantitative.if it is available can u try it.

You can see the literarute regarding this. Check for the appropriate chiral organocatalyst for the same. Also please refer to the Prof. Sudalai's research papers from NCL Pune. He has some papers in this regard.

ruduce this ketone with 9BBN. i. e. 9 bora bicyclo nonane. yu will get the chiral alcohol.

instead of this catalyst yu will also use Bakers yeast fr this u must understand how many carbon are present in ur ketone

Dear Friends,

Thanks a lot for your suggestions. Your suggestions are valuable and worth trying.

Best Regards

Rajesh

BisP, TCFP, and many other bisphosphine Ir, Ru-complexes work so well

Al-complex such vitride in selective mole if we use then we can reduce complete or partial for the ketone functional group & Biological enzymes also reduce the carbonyl group selectively.

William Berkowitz sent you a message on ResearchGate. (This may be a repeat).

Hi,

Asymmetric reduction of an amide of alpha-amino-acetophenones, see any one of the following, then hydrolyse the hydroxy-amide product back to the amino alcohol.

With borane-THF, borrole, (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza in toluene, T= 5 - 20 °C

Coe, Diane M.; Perciaccante, Rossana; Procopiou, Panayiotis A.; Organic and Biomolecular Chemistry; vol. 1; nb.

7; (2003); p. 1106 – 1111

in ethanol, water, Time= 504h, T= 32 °C , baker's yeast, sucrose, Yield given. Yields of byproduct given. Title compound

not separated from byproducts

Izumi, Taeko; Fukaya, Katsumi; Bulletin of the Chemical Society of Japan; vol. 66; nb. 4; (1993); p. 1216 - 1221

With palladium (II) trifluoroacetate, hydrogen, (R,R)-Me-duphos in 2,2,2-trifluoroethanol, p= 10343 - 20685.9Torr ,

Heating, Title compound not separated from byproducts

Wang, You-Qing; Lu, Sheng-Mei; Zhou, Yong-Gui; Organic Letters; vol. 7; nb. 15; (2005); p. 3235 - 3238

With trans-RuCl2[(R)-xylbinap][(R)-daipen], potassium tert-butylate, hydrogen in isopropyl alcohol, tert-butyl alcohol,

Time= 20h, T= 25 °C , p= 6080.41Torr , Catalytic hydrogenation, Title compound not separated from byproducts.

Ohkuma, Takeshi; Ishii, Dai; Takeno, Hiroshi; Noyori, Ryoji; Journal of the American Chemical Society; vol. 122;

(2000); p. 6510 - 6511

Bill

Try chiral BINOL to ketone , it will work. Search literature for reduction by chiral binol's.

Thank u to all

You can reduce using H2 in the presence of chiral BINAP or Baker's yeast in the presence of sugar

Try sodium cynoborohydride

You can reduce using asymmetric transfer hydrogenation by RuCl2-p-cymene combined with chiral aminoalcohols or chiral diamines in isopropanol in the presence of NaOH under nitrogen.

The reagent name is called CBS reagent.Its a chiral reducing agent to make chiral alcohol from ketone

You might want to try DIPCl, HC Brown's reagent. We got very high ee's when using DIPCl to reduce pro-chiral alpha amino ketones to the corresponding amino alcohols. DIPCl has the added advantage of being available in both enantiomers of alpha-pinene, so obtaining R or S enantiomers after the reduction is quite direct.