I work with the assessment of production system configurations with respect to operational, economic and environmental performances.

A production system configuration is meant to be a facility with specific equipment, layout, numbers of operators, etc.

The assessment involves a comparison of the configuration being studied with other alternative configurations (for instance, a case "yes, new equipment" VS "no new equipment, status quo"). The comparison is being done through discrete event simulation.

Now, my doubt is on how to make sure that the evaluation compare the two cases fairly. 

Beyond the fact that the two systems get supplied with the same input distribution of pieces to process, I wonder if I have to make sure that the two systems are evaluated and compared with the same level of performance operations wise (e.g., same yield, same efficiency).

To me, this is to make sure that both systems' operations are managed by the same people having the same expectations in terms of efficacy of operations management. 

An example of this approach is to optimizing both systems firstly and then compare the resulting performances. 

What are your thoughts on that?

Every idea and source is most welcome. I will particularly appreciate previous experiences in discrete event simulation of production systems and considerations about design of experiment in the context of production systems and operations.

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