I would be happy to received explicit examples with compound name or structural classes, where the minipig is "closer" in translation towards the human situation. And why is that (target similarity, safety, metabolism etc.)?
Many thanks in advance.
Paul Taslimi
A good example is in the development of EGFR inhibitors. The inhibition of the wild type kinase generally displays as skin toxicity. Minipigs, having a dermis that is rather similar to humans, recapitulate this toxicity better than other systems.
0 votes
0 thanks
Tomasz Grabowski
Dear Paul
Trastuzumab, tocilizumab, rituximab, adalimumab, anakinra, entanercept, somatropin, insulin - subcutaneous pharmacokinetics all of that drugs was tested using minipig model,
Kind regards,
Tomasz
0 votes
0 thanks
- Badges
- Science topic
- Similar topics
- Medicine
- Disease
- Disease Models
- Animal Models
More Paul Germann's questions See All
Similar questions and discussions