This is a broad question you have to select any group of drugs that you may wish and I can explain to you how they lower blood pressure. Send me one group at a time and will give you full details of the mechanism of action

Use the formula: ABP = CO X TPR then plug in what a class of drugs will

do to the parameters in question. This is the simplest way to remember how drugs will lower ABP. Extend the formula by remembering that HR & SV regulate CO and that CF and VR contribute to SV.

Many drugs can be lower the blood pressure by different mechanism.The blood pressure can be lower without drugs. If you explain about the drugs thatt you want to know is possible answer the question.

Very interesting question, which is not as simple as being thought by the questioner. In my opinion, the understanding of drug metabolism is mandatory to a physician. Most of the cardiac drugs play a role of blood thinning and thus lowering the blood pressure. Further detailed mechanism can be explained by a cardiologist.

Dear Dr. mishra, most of the cardiac drugs act by affecting the preload, after load or pripheral vascular resistance. Other drugs may act by affecting certain hormons e.g. Renin Angiotensin system but it has nothing to do with blood thining.therefore, the question should be addressed for specific group of drugs so we can answer fully and explaine all the operating mechanisms. Understanding the mechanism of action is definitly needed but the metabolism may not be so essential for the physicians to understand.

Dear Dr. Abdulaziz Saddique,

I do understand what you mean to reflect through your statement. As far as biochemistry is concerned, it is mandatory to be coordinated with pharmacokinetics, drug metabolism and finally detoxication of drug. That's why at graduate level in I year, physiology and biochemistry are taught.

Dear Dr. mishra

I fully agree with you regarding the pharmacokinetics, and I wish dearly if the physicians understand drug metabolism because a lot of drug interactions and reactions depends on that. I have suffered a lot with even graduate students to put things together and link pharmacology with biochemistry, kinetics and mechanism of action but they dont see the value. May be future physicians will learn. Good luck

Dear Dr. Abdulaziz Saddique,

Nice to hear that you are convinced with my statement. I would like to be in continuous contact with you.

With thanks and kind regards,

Sanjay

I do agree with Prof. Mishra.

I agree with Professor Mishra alike.

It is very interesting debate.