I want to understand the physical significance of the product of D (Delta I) (term of diffusion with D the diffusion coefficient) and S the number of the susceptible.
I'm not sure that I understand the question fully. However in the simple one dimensional SI epidemic model, the coefficient beta (or k) represents the no. of contacts per unit time of all population members (susceptible or not). The no. of susceptible contacts/unit time is thus beta S/n, where n is total population.S the susceptible population.
If you are considering a 3 dimensional spatial model, the time coefficient could vary with direction.
Yes, the coefficient beta represents the no. of contacts per unit time of all population members (susceptible or not) represented by the term (beta*S*I) now what represents the term (k*S*delta(I)) per unit time,