It is generally understood that the McMurry reaction is an organic reaction in which two ketone or aldehyde groups are coupled to form an alkene using a titanium chloride. Can we use some other catalyst instead of titanium chloride herein? I have planned to get heterocyclic ketones as the reaction substrate.
Dear Khurshed,
There are new ligand modified Ti catalysts and other metal catalyst including enzymatic reactions available:
J. Org. Chem. 1997, 62, 14, 4566–4567
Carbon–Carbon Bond Formation
K. Suzuki, M. Tamiya, in Comprehensive Organic Synthesis II (Second Edition), 2014
Non-Titanium : Photo-redoxArticle Photoinitiated Carbonyl-Metathesis: Deoxygenative Reductive ...
Synthetic Methods VI – Enzymatic and Semi-Enzymatic
R.J. Kazlauskas, U.T. Bornscheuer, in Comprehensive Chirality, 2012
Dear Khurshed Bozorov many thanks for this very interesting technical question. When you hear McMurry reaction, you immediately think of low-valent titanium as coupling reagent. However, according to the link cited below, a number of other metals can also be employed as metal reagents in this reaction. These include e.g. aluminum, zirconium, vanadium, niobium, molybdenum, tungsten, and zinc. The respective original research articles are cited in the following link:
McMurry coupling
http://organicreactions.org/index.php/McMurry_coupling
Dear Frank T. Edelmann , thank you very much for your valuable comments and feedback regarding on my question.
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