You could check on this and follow forward:

•Nucleic Acids Res. 2011 Mar; 39(6): 2470–2481.

Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids.

•Molecules 2015, 20, 17511-17532. 

G-Quadruplex Forming Oligonucleotides as Anti-HIV Agents.

•British Journal of Cancer (2013) 109, 2579–2586. 

First-in-human Phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide to exon 4 of the androgen receptor mRNA in patients with castration-resistant prostate cancer.

Hey Ehsan , Do you mean as a RT inhibitor ? 

I think RT has ability to process LNAs for the polymerization. There are some studies where DNA polymerases proved to incorporate LNAs in to a growing strand on a template. 

http://pubs.rsc.org/en/Content/ArticleLanding/2010/NJ/b9nj00628a#!divAbstract

Polymerase directed incorporation studies of LNA-G nucleoside 5′-triphosphate and primer extension involving all four LNA nucleotides

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0035990

Efficient Reverse Transcription Using Locked Nucleic Acid Nucleotides towards the Evolution of Nuclease Resistant RNA Aptamers