There is report that depletion of glutathione causes liver injury due to oxidative stress. Can we supplement direct glutathione for increasing the content of this glutathione depletion to get rid of liver disease in Poultry?
It depends on the goals you are asking for. If you are working in an experimental model, as a reseacher, you only need to respect bioethic aspects. If you are thinking in therapeutics you need to verify if glutathione is officially authorized for that propose.
In human dietetics gluthatione is used as food supplement. The glutathione is taken orally for treating cataracts and glaucoma, preventing aging, treating or preventing alcoholism, asthma, cancer, heart disease (atherosclerosis and high cholesterol), hepatitis, liver disease, diseases that weaken the body’s defense system (including AIDS and chronic fatigue syndrome), memory loss, Alzheimer’s disease, osteoarthritis, and Parkinson’s disease. Glutathione is also used for maintaining the body’s defense system (immune system) and fighting metal and drug poisoning.
Glutathione is breathed in (inhaled) for treating lung diseases, including idiopathic pulmonary fibrosis, cystic fibrosis, and lung disease in people with HIV disease..
i think that's is good idea.,.because glutathione need for reduce negative effect of heat stress
I agree with Bernardo. You can use it as per the reported/reccommended purposes. Regards
This is not a direct answer to your question but a suggestion for an alternative approach. I agree with the others that direct supplementation with glutathione can be useful. However, Giamattei found alpha lipoic acid (ALA) supplementation normalized liver function in schizophrenia patients. Oxidative stress and a low GSH/GSSG ratio are characteristic features of this disease. Suh found ALA supplementation increased glutathione synthesis and GSH levels through activation of the Nrf2/ARE/GCL pathway. You may find ALA a more cost-effective alternative to GSH.
Giamattei, L., 1957. Thioctic acid in therapy of schizophrenia. Osp. Psichiatr. 25, 221–228.
Suh, J.H., Shenvi, S.V., Dixon, B.M., Liu, H., Jaiswal, A.K., Liu, R.M., Hagen, T.M., 2004. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis.
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