This depends of the specific area in physics - where interest is focused.
It is known phenomenon in thermal physics, elasticity, but generally it's unsolvable problem for most of the fields - because you need to consider anyway - but the internally structured media/material.
This premises immediately transfer you to the structural, composite, poly-phase materials - at any level of spacial consideration.
It's known that biological structures, tissues are extremely complicated spatially and physically.
Why is that ? Because nature is actually very seldom, or even never creates structures with the excess of resources? So why?
Also - because in almost all physics and biology sciences universities cannot teach and study the Scaled, Hierarchical materials correctly - these are the tasks of not present score of university professors or other workers in materials science right now.
The one-scale even many phase materials design cannot perform properly with the current teachings in universities. They teach phenomena at the one scale physics - and this is not enough and incorrect. Sorry for them.