Hi Shyam Baboo
Please go through the following information, you will find something useful for you:
The study of experimental colon carcinogenesis in rodents has had a remarkably long history, dating back almost 80 years (1). Perhaps the earliest published study of Lorenz et al. (2) demonstrated tumorigenesis in the forestomach and intestine of mice following feeding with the polycyclic aromatic hydrocarbon, methylcholanthrene. Lisco et al. (3) reported that feeding radioactive yttrium to rats induced a high proportion of colon tumors. Walpole et al. (4) reported that white rats given injections of 4-aminodiphenyl and 3,2-dimethyl-4-aminodiphenyl developed colon tumors. When large quantities of cycad flour were fed to rats, adenocarcinomas in the colon arose in some of the animals. The carcinogen in cycad flour was subsequently found to be cycasin, a form of methylazoxymethanol (MAM) (5).
References:
1. Krebs C. Experimenteller Alkoholkrebs bei weissen Mäusen. Z. Immun. Exp. Therap. 1928;50:203–218.
2. Lorenz E, et al. Intestinal carcinoma and other lesions in mice following oral administration of 1,2,5,6-dibenzanthracene and 20-methyleholanthrene. J. Natl Cancer Inst. 1941;1:17–40.
3. Lisco H, et al. Carcinoma of the colon in rats following the feeding of radioactive yttrium. Cancer Res. 1947;7:721–725.
4. Walpole AL, et al. The carcinogenic action of 4-aminodiphenyl and 3:2′-dimethyl-4-amino-diphenyl. Br. J. Ind. Med. 1952;9:255–263. (pdf attached)
5. Laqueur GL. Carcinogenic effects of cycad meal and cycasin, methylazoxymethanol glycoside, in rats and effects of cycasin in germfree rats. Fed. Proc. 1964;23:1386–1388.
Link to the full text of above matter: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639048/pdf/bgn267.pdf
Gud Luck and regards
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For details please visit here: http://cancer.global-summit.com/middleeast/
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