Could you elaborate more on your suggestive "normal" approaches. What constitutes them?The inhibitory channels can be many and multiple!Treatment can have more options and actions. So, be more elaborate, focused in the query, thank you!

First of all, Thank You for your kind suggestion  Khan Sir. 

Frankly speaking, I don't have much idea I just think and put this question forward.Because while I was reading the paper over cancer, I found most of the article focused on inhibition of angiogenesis and this is the key area in cancer research. Meanwhile, I also came across the formation of aberrant leaky blood vessels in cancer disease and these leaky blood vessels are one of the major culprits in the result of metastasis stage of cancer. So to overcome cancer inhibition of angiogenesis may be a positive approach but in consequence of that, it may also affect normal angiogenesis of body.  So, in my opinion, I think that if we try for the proper well formation of blood vessel then it will be beneficial for the normal cell as well as cancer condition by reducing the chances of metastasis stage up to some extent if not all.

Few of the paper also discussed the "Promiscuous Drug"

Sir, I may be totally wrong due to the insufficient amount of knowledge.  I am naive and trying to learn.