I am designing a 50w power amplifier using ADS tool To simulate that I am using s2p file. I am not getting harmonic balance simulation results properly, can we HB simulation using s2p file or not.
Just make sure that the S-parameter files are used in a way that makes sense. HB simulations are very useful to obtain a steady state response of non-linear circuit components (think a PA driven into compression). S-parameters are undefined in large signal operation, which means that if you use S-parameters of a transistor, let's say, you might get nonsensical results. However, if you use the S-parameter files of passive components, everything should be fine. This comes from the definition of S-parameters, where no non-linear effects are taken into account.