Heart attack is an medical emergency. Treatment received by the patient in the first
' Golden Hour ' is crucial in limiting the damage. However, many heart attacks are " Silent ", i.e.does not cause any symptoms. In other cases, patients attributes symptoms to other less serious ailments like acidity or overwork, delaying treatment and risking lives.
Current AI models and blood/imaging tests detect heart attack risk only as prediction, which spread over a period of 5 to 10 years. I believe that if we can detect impending heart attack 24 - 72 hours before, we are able to save 99 % lives, if not 100 % .
Too many factors to determine, more over many people have “silent” MIs. Are you wanting to find a bio marker? Or a specific invasive test?
A blood biomarker test or non-invasive tests like breath analyzer test will be helpful.
This was the hypothesis of the BIOMArCS study High-Frequency Biomarker Measurements of Troponin, NT-proBNP, and C-Reactive Protein for Prediction of New Coronary Events After Acute Coronary Syndrome | Circulation (ahajournals.org)
Myeloperoxidase is biomarker produced by white blood cell from inflamed blood vessel can detect Impending heart attack 2-3 month in advance. Newer Smart watch are based on above technology to detect Impending heart failure
In current clinical practice there is no biomarker that can predict imminent myocardial infarction.
Myeloperoxidase is a enzyme produced by neutrophil and macrophage is powerful pro-oxidative and pro inflammatory properties and useful marker of plaque instability. Can be detected in blood 1-2 week in advance
It seems that myeloperoxidase would have a high sensitivity but low specificity; similarly high PPV, low NPV
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwiz5qaBtv_1AhWqxDgGHZY2DWMQFnoECB4QAQ&url=https%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%2Fjournal.pone.0154333&usg=AOvVaw2mMCw6UOQuCQEAQQQaN-iG
Yes JC Lee Sir Myeloperioxidase have high sensitivity but specificity is low but we have to also look for warning sign of impending heart attack like Chest pain pain radiating to left arm , jaw pain and also recall presentation of previous attack can manifest hour or week before the impending heart attack
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