Ayurveda has concept of Rasa, Vipaka, & Virya which may be correlated with Pharmacokinetics and pharmacodynamics. And here I want to know how can we correlate the AVASTHHA -PAK, NISTHAA-PAK (A stages of Ayurvedic pharmacokinetics) with phases of metabolism.
Phase -I & II are the stages of metabolism in which body try to make the xenobiotic more polar so that it can get eliminated as soon as possible. Since the product of these phases of metabolism may also acts a active pharmaceutical moiety (e.g. in case of prodrug).
Yes please. But remember that they are not equivalent but only stages.
CONSEPT OF PERSONALIZED MEDICINE AND AYURVEDA
http://chakrapany.blogspot.in/2008/10/consept-of-personalized-medicine-and.html
Ayurveda and Metabolism: Ayurveda refers the term “Vipaka” (Vishishta Paka) for the metabolism, result of three phased “Awastha Pak”- Primary Metabolism (Madhur, Amla, Katu) and “Nishtha Paka”- Final Metabolism. “Vipaka” is the “Final Metabolic Juice”. According to Ayurveda the diets and drugs give similar pharmaco-dynemic action during the “Awasthapaka” (Madhur, Amla, Katu), but after the “Nishtha Paka”, the dominant property of diet/drug shows its particular action. Ayurveda puts the “Vipaka” into first consideration regarding the assimilation, absorption and excretion of diet / drug. Body temperament of once plays specific role for the digestion of diet / drug but it may varies from one to other. That is why Ayurveda advocates – Select the medicine and its dose individually based on the examination of “Roga Parikshan” (Diagnosis) and Rogi-Pareeksha (Examination to the Individual) with the help of - Prukriti Parikshan, Dashawidh & Trividh Pareekshan, etc. Further refers “Take the drug wholesome”.
@Ram Nath Mishra .......I wanted to hear these kind of answers ..thanks for your reply......!!!!!
I'm very happy to see your views in line with my perspective as well......!!!!!!
I don't know much about the ayurvedic AVASTHHA -PAK and NISTHAA-PAK as much in detail but to my limited knowledge Avastha-pak is some thing like a passage of drugs or eatables after eating, churning from mouth to large intestine during which absorption takes place... this is not Phase I metabolism as Phases of metabolism starts in liver only and avastha-pak has nothing to do with liver... now coming to nishtha-pak which seems final metabolism of the absorbed juices after which the drug action or nutrition starts... This seems to me like the real metabolic phases in liver classified under single name nishtha-pak. Correct me if am wrong. !!!!
Dear Ankur Sir,
Thanks a lot for your valuable and interactive views..!!
But to integrate and understand steps for integration and/or integrative PK we need to understand Ayurvedic views about drug metabolism and therefore we have to start from Avasthapak.
I'm looking forward for this type of interactive discussions form both feilds (Ayurveda and Modern science...)
Regards
Swapnil
@ Swapnil P Borse please go through this my article on Awastha paka ... https://www.researchgate.net/publication/343537124_A_Critical_Appraisal_on_Digestive_System_Avastha_Paka_of_Ayurveda_in_the_Modern_Physiological_Perspective
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