I have seen several patients who take vitamin B12 as a supplement who have developed insomnia. I am trying to find evidence supporting causality.
Yes, when using excessive doses of vitamins of group B is the development of intoxication of the human body. Hypervitaminosis of vitamins B1, B2 and B6, can cause fatty liver. Among the elements of group B are the most toxic B6 and B12. Allergic reactions are observed, mainly, the overabundance of vitamins B1, B2, B6 and B12.
When taking large amounts of b vitamins may develop intoxication in the form of General excitement, insomnia, increased frequency of pulse, headache, dizziness, sometimes develop seizures.
From insomnia work well melaxen along with glycine.
If tehere is a vit B12 deficiency in your body taking B12 preperats help to insomnia, but if there is high B12 level in serum, taking B12 cause insomnia. Because of intoxication generally causes ajitation and so insomnia.
I agree that unnecessary doses of vitamins of B-group may cause insomnia because of the extra-stimulating effect on the CNS.
https://examine.com/supplements/vitamin-b12/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174691/
http://www.uofmhealth.org/health-library/hn-2924006
https://www.researchgate.net/profile/Max_Chartrand
Hypothesis: if added to TOO MUCH VITAMIN B12, SAMe will exacerbate adverse effects of hypervitaminosis including insomnia, anxiety, frequent urinatiion.
QUESTION: IS THERE ANY EVIDENCE, CLINICAL OR PRECLINICAL, SUPPORTING OR REFUTING THIS HYPOTHESIS?????
As far as I know, no consistent data exist on B12 hypervitaminosis. It might well be that chronic overdose leads to toxic effects as described, but as well that people are taking vitamins to do themselves something good when in depressed and anxious mood.
Dirk
Vitamins if taken in too high doses for too long can cause problems
Lew
Dear Lew,
papers on this issue:
http://www.drweil.com/drw/u/QAA50582/can-too-much-vitamin-B-cause-problems.html
Article Vitamins and Sleep: An Exploratory Study
Article Successful Treatment of Human Non-24-Hour Sleep-Wake Syndrome
Article B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review
I understand that I am an "n of 1", but I had normal serum vitamin B12 and got a B12 injection to help a friend with graduation requirements yesterday. Last night I experienced extreme restlessness, increased urination and am feeling slightly anxious today which is very unlike me. It is incredibly hard to find literature on the topic but I cannot attribute this to anything else.
I've noticed insomnia by some people using methyl b12, but not by people using hydroxocobalamine.
I always advice to take it together with methylfolate or folinic acid and a b-complex.
The world of micronutrients still has many gaps, and the specific case of vitamin b12 is particularly complex given the clinical importance of its levels, which are low, but also high. In this sense, in complement to the debate question, I want to share with you the following manuscript detailing the aspects associated with high levels of vitamin b12.
Article Hipervitaminosis B12 una mirada desde la atención primaria
The world of micronutrients still has many gaps, and the specific case of vitamin b12 is particularly complex given the clinical importance of its levels, which are low, but also high. In this sense, in complement to the debate question, I want to share with you the following manuscript detailing the aspects associated with high levels of vitamin b12.
Article Hipervitaminosis B12 una mirada desde la atención primaria
This can happen on the day they take methylcobalamine, specially if the take it late in the afternoon. Injections with hydoxycobalamine don't give this reaction.
Also, if they use b12 (all kinds) without the other b vitamins, they create a deficiency in the latter. That also can cause insomnia.
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