Can the incidents rate of a control group of RCT be compared with the observational studies (cohort design) in a meta analysis?

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Mansour Abdullah Alshehri

Hi Mari

There is an article that discuss this issue in details and may help you. The article name is 'Should Meta-Analyses of Interventions Include Observational Studies in Addition to Randomized Controlled Trials? A Critical Examination of Underlying Principles'.

https://www.ncbi.nlm.nih.gov/pubmed/17712019

Good luck!

Mari Takashima

Thank you, Dr Kumar and Dr Alshehri for your answers and suggestions. Could I also ask, if I only use the control group of RCTs, should I use quality assessment tool for 'observational study' [Newcastle-Ottawa Scale or NIH scale (https://www.nhlbi.nih.gov/health-pro/guidelines/in-develop/cardiovascular-risk-reduction/tools/cohort) ] or for 'RCT ' (Cochrane ROB tool) ? Since I am separately using the RCT control group, I possibly can't assess the quality of the study as I am taking away the benefit of randomisation. Which assessment scale would you use so it will be applicable?

Thank you!