I am examining the immunosuppressive activities of several medicinal plants on pristane-induced lupus. The result of the cytokine levels and urine protein are promising, but the histopathological analysis still show some damages on the organs. Is it possible that the improvement of the organ function (showed by the level of urine protein and cytokines) happens earlier/improve first than the repair of anatomical damage?
I have tried to find a suitable reference but have not found one.
Thank you.
Dear Meutia Faradilla,
Histological damage, to certain degree, could be seen in spite of nearly normal blood parameter. This is most likely depend on the organ examined and the area of which the specimen is taken.
Best wishes
Schachtrupp A, Lwong G, Afify M, Graf J, Toens C, Schumplik V. (2005): Fluid resuscitation preserve cardiac output but cannot prevent organ damage in a porcine model during 24 hour of intra-abdominal hypertension. Shock, 24 (2) 153-158
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