The use of a combination of natural product/herb and medicine is still difficult to establish the effects produced by them.
Can anyone share about the step in investigating the combination effect of plant and a single compound drug in inhibiting enzyme?
The Chou and Talalay method is widely used. See the following papers:
(1) Chou, T.; Talalay, P. Quantitative Dose-Effect Relationships : The Combined Effects of Multiple Drug or Enzyme Inhibitors. Adv. Enzym. Regul. 1984, 22.
(2) Chou, T. C. Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method. Cancer Res. 2010, 70 (2), 440–446.
(3) Chou, T.; Kurin, E.; Mučaji, P.; Nagy, M.; Hidalgo, M.; Sánchez-Moreno, C.; de Pascual-Teresa, S.; Iacopini, P.; Baldi, M.; Storchi, P.; Sebastiani, L.; Chou, T.; Wang, S.; Wang, D.; Liu, Z. Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies. J. Food Compos. Anal. 2010, 67 (3), 621–681.
(4) Chou, T. C. Frequently Asked Questions in Drug Combinations and the Mass-Action Law-Based Answers. Synergy 2014, 1 (1), 3–21.
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