I am looking for the mouse/rat model of septic peritonitis. Can someone suggest working method or give publication link. Thanks
Animal Models of Anemia of Inflammation
Seth Rivera, M.D., Ph.D.1 and Tomas Ganz, Ph.D., M.D.1,2
Abstract
Anemia of inflammation (AI) is a complex multi-organ response to inflammatory disorders. Because AI can result from many infectious and non-infectious inflammatory diseases, multiple mechanisms may contribute to its pathogenesis including iron restriction, direct erythropoietic suppression, shortened red cell survival or frank hemolysis. Animal models have been helpful in the study of the mechanisms of AI and its potential treatments but each model reflects distinct aspects of this heterogeneous syndrome. It is therefore important to study a variety of models of AI. This review focuses on the use of infectious and noninfectious mouse models of inflammation that have been shown to manifest anemia. We review many of the models reported in the literature or developed in our laboratory, and discuss their respective merits and drawbacks.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755601/
Hi Vano, there is a colon ascendens stent peritonitis model of polymicrobial septic peritonitis
see for example: J Immunol. 2012 Jun 15;188(12):5833-7. doi: 10.4049/jimmunol.1200038. Epub 2012 May 14.
Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis.
Gais P1, Reim D, Jusek G, Rossmann-Bloeck T, Weighardt H, Pfeffer K, Altmayr F, Janssen KP, Holzmann B.
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