Actually I am trying to study a protein which is phosphorylated by CDK1. So I cannot use RO3306 but I need to arrest cells at late G2 followed by temporally controlled release into the subsequent Mitotic subphases.
Maybe ganetespib (STA-9090) - a novel and potent HSP90 inhibitor you use to induced G2/M cell cycle arrest.
Ganetespib (STA-9090) a novel and potent HSP90 inhibitor for its activity in gastric cancer cell lines. Ganetespib significantly inhibited the proliferation of AGS and N87 human gastric cancer cell lines and potently induced G2/M cell cycle arrest and apoptosis.
Article Ganetespib induces G2/M cell cycle arrest and apoptosis in g...