I am working on a thesis using a polyherbal formulation of several herbs and looking for merits and demerits of large vs. small particle size, 80 sieve, 120 sieve, fine, coarse, very fine.... Can someone point me to some reading, esp if it is in Bhaisajya Kalpana and Ayurvedic pharmaceutic? I think pharmacies that make powders must have examined this issue, but can't find anything...
In general the smaller particle size the larger surface area the higher dissolution rate and vice versa.
Bhaswati jee, usually the coarse powder (20 or 40 sieve)of the plant material is preferred if you are extracting them with solvents. If you mean a powder dosage form, I would rather suggest to go for granules.
check this out..
Strategy for analysis and screening of bioactive compounds in traditional Chinese medicines. Journal of Chromatography B, Volume 812, Issue 1, Pages 71-84
Xiaodong Huang, Liang Kong, Xin Li, Xueguo Chen, Ming Guo, Hanfa Zou
There is lot of literature available on this aspect. Particle size is very important in Unani Medicine also.
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