I study the elimination of nanoparticle (Size < 3 nm), which stay in the proximal tubule for 1 week. How long might they stay here? Have you got reference?
Article Proximal Nephron
Not quite sure how I can answer this question. Most of low molecular wt. proteins, small peptides, nutrients, amino acids, vitamines, minerals, DNAs, RNAs, siRNAs circulating in the plasma would be rapidly filtered through the glomeruli in the kidney, and taken up by proximal tubules. Most of these reabsorbed substances would be returned to the circulation and some of them may be degraded in the proximal tubules in lysosomes. I guess that your nanoparticles would be taken up by the proximal tubules as well. If you give nanoparticles to animals as a bolus injection, it may stay for a couple of days dependent on the properties of your nanoparticles. If you do constant infusion, they may remain in the proximal tubule as long as you infuse them, and stay for days or weeks after you stop the infusion......
Thanks for this answer. The particles stay for 2 weeks approximately (after I can not find them anymore). So I would like to find a good reference with similar results for reference in an article... If you have any of your references, I would be pleased to cite it/them. Thanks again for answering !
No, I don't have a particular reference ready for you to cite. However, you may use this one to expand your searching for a good reference.
Biomed Res Int. 2013;2013:353695. doi: 10.1155/2013/353695. Epub 2013 Jul 17.
Uptake of gold nanoparticles in several rat organs after intraperitoneal administration in vivo: a fluorescence study.
Abdelhalim MA.
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